I have been working and studying these past few days, and time flies by.
Combined with the artificial intelligence course content I have studied in the past few days, and several recently published articles. As well as the impact of structures that were previously considered. Our research on the pathogenic mechanism and drugs of the new coronavirus may require a team from various disciplines, including biologists, chemists, physicists, mathematicians, artificial intelligence technology experts, etc., to form a joint research team. Targeting the mechanisms currently working in three-dimensional RNA.
The outbreak of the new coronavirus epidemic hopes to create a mechanism that integrates the strengths of various disciplines to race against time to solve practical problems and generate innovative theories. Establish a temporary project similar to the Manhattan Project to systematically study the pathogenic mechanism, solutions, related drugs, and vaccine production of the new coronavirus. And after the epidemic is over, a complex research organization similar to the "Santa Fe Institute" will be left behind, as well as a set of response management mechanisms for sudden epidemics.
Before the emergence of systematic engineering, there can be a self-organizing process.
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Full-length structure of ACE2:
Recently, Zhou Qiang's laboratory at Westlake University used cryo-electron microscopy technology to successfully analyze the full-length structure of ACE2, the receptor for the new coronavirus.This is the first time in the world that the full-length structure of ACE2 has been resolved.The relevant research content was launched on the preprint platform bioRxiv at around 3 a.m. on February 19th, Beijing time. This is also an important achievement of the emergency scientific research task on the prevention and control of new coronavirus pneumonia in Zhejiang Province undertaken by Westlake University.
After the outbreak of pneumonia caused by the new coronavirus infection, scientists from the Wuhan Institute of Virology discovered that the new coronavirus, like the SARS virus in 2003, also enters human cells by recognizing the ACE2 protein.ACE2 is the key for the "new coronavirus" to invade the human body。Research has found that when the SARS virus and the "new coronavirus" invade the human body, ACE2 is like a "door handle". The virus grabs it, thus opening the door to enter the cell.
Citation:(version using Google Translate)
Like other message-passing neural networks, directed message-passing neural networks (Chemprop) learn to predict molecular properties directly from the molecule's graph structure, where atoms are represented as nodes and bonds as edges.For each molecule, we reconstructed the molecular graph corresponding to each compound's SMILES string and identified the set of atoms and bonds using the open source software package RDKit (Landrum, 2006).Next, we initialized a feature vector like Yang et al.(2019b), for each atom and bond based on computable features:
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1 Atomic characteristics: Atomic number, number of bonds per atom, formal charge, chirality, number of hydrogen bonds, hybridization, aromaticity, atomic weight.
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2 Key characteristics: Bond type (mono/bis/tri/aromatic), conjugation, ring membership, stereochemistry.
https://www.cell.com/action/showPdf?pii=S0092-8674%2820%2930102-1
Who "hidden" the Wuhan coronavirus for 13 days?
Jiang Yanyong:I am not a hero, I just told a few truths and reflected the situation truthfully as I know it.It is not enough for one person to tell the truth. If everyone wants to tell the truth, there will be nothing to hide.If everyone tells the truth, the country will naturally get better.If no one dares to tell the truth, it will be difficult for the country to prosper.If everyone tells the truth, there will be hope for the country and things will be easier to handle.
Machine-translated from the Chinese original 记录0228|新冠病毒机制+AI|自然的舞蹈|反思 (published 2020-02-29). WeChat original ↗